A MiddLab Project

The effects of prolonged exposure to prolactin upon adult neurogenesis

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For his thesis research, Tyler Prince (’11) is continuing our research with prolactin to examine the effects of prolonged exposure to prolactin upon adult neurogenesis. This summer, he conducted histological staining for newly proliferated cells in the hippocampus (See pictures).The hippocampus is an area of the brain that plays a critical role in the processing of spatial and temporal memories and is involved in working memory more generally. Therefore, the growth of new nerve cells is of particular interest in this brain region, and our research has implications for the treatment of neurodegenerative diseases such as Alzheimer’s disease and chronic depression.


Tyler Prince

Mark Spritzer
Assistant Professor of Biology

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Full Project Description [DOC]

Spritzer et al Figure 2

Evidence that an acute low dose of the hormone prolactin caused an increase
in cell proliferation within the hippocampus region of the brain

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