In a January 2011 Winter Term Class, “Twenty-First Century Global Challenges,” 21 Middlebury students studied great challenges of our time – including wide-scale poverty, climate change, and the struggle for human rights. They then analyzed how social entrepreneurs – individuals and groups who are developing new ways to attack systematic problems – are taking on these challenges. For example, Nina Cameron ’12 studied how the Global Network is trying to reduce the prevalence of neglected tropical diseases; Erin Kelly ’13 studied how the University of the Peopleis providing tuition-free higher-education throughout the developing world. The students also spend much of the course developing a vision for a new center for social entrepreneurship based at Middlebury College. On this MiddLab, we report the ongoing results of this work.